Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(in print)
ISSN :2433-2410(online)

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Shimane Journal of Medical Science 24
2007-12-01 発行

Anti-glomerular basement membrane antibody associated with human parvovirus B19 infection

Horie, Akiyoshi
Yotsumoto, Yuka
Yamaguchi, Seiji
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Description
An eleven years old girl developed glomerulone-phritis, showing positive antibody against glomerular basement membrane (anti-GBM) associated with acute human parvovirus B19 (HPVB19) infection. She was admitted with fever, rash, and joint pain.
Additionally, hematuria, proteinuria, and hypocomple-mentemia were present. HPVB19 DNA and anti-GBM antibody were positive in blood. A kidney biopsy showed mesangial proliferative glomerulone-phritis. Subsequently, steroid pulse therapy was given, followed by oral prednisolone and cyclophosphamide, After the steroid pulse therapy, the urinary findings improved, and anti-aBM antibody became undetectable, also the glomerulonephritis has not recurred. The HPVB19 infection appeared to have induced the production of anti-GBM antibody in this patient.
NCID
AA00841586