Anti-glomerular basement membrane antibody associated with human parvovirus B19 infection

Abstract

An eleven years old girl developed glomerulone-phritis, showing positive antibody against glomerular basement membrane (anti-GBM) associated with acute human parvovirus B19 (HPVB19) infection. She was admitted with fever, rash, and joint pain.
Additionally, hematuria, proteinuria, and hypocomple-mentemia were present. HPVB19 DNA and anti-GBM antibody were positive in blood. A kidney biopsy showed mesangial proliferative glomerulone-phritis. Subsequently, steroid pulse therapy was given, followed by oral prednisolone and cyclophosphamide, After the steroid pulse therapy, the urinary findings improved, and anti-aBM antibody became undetectable, also the glomerulonephritis has not recurred. The HPVB19 infection appeared to have induced the production of anti-GBM antibody in this patient.