A 63-year-old woman with scleroderma who received long-term hemodialysis complained of acute eyelid swelling, proptosis, and pain in the right eye. Fever and leucocytosis were also noted. A computed tomography scan showed high density in the right orbit. One week later both orbits exhibited signs of deterioration. Intravenous antibiotic therapy resolved the orbital infection after one month. This report describes a rare case of bilateral orbital cellulitis in an elderly woman receiving hemodialysis.