A previously healthy 75-year-old man received intravenous antibiotics for fever. After treatment, he experienced a sudden loss of vision and demonstrated intraocular hemorrhages and whitish retinas bilaterally. A biopsy of the liver disclosed an abscess. Staphylococcus epidermidis grew from vitreous aspirate of the left eye. The left eye was eviscerated 1 1/2 months after the onset, and the right eye became phthisical, despite systemic and intravitreal antibiotic therapy.