Combined administration of low-dose pregabalin and tramadol hydrochloride/acetaminophen combination tablets significantly reduced refractory myelopathic pain （bilateral leg pain） caused by spinal cord tumor/syringomyelia in a woman in her 80s. Through mutual interaction, combined administration of pregabalin and tramadol hydrochloride/acetaminophen combination tablets, which have different mechanisms of action, might have had an early, beneficial analgesic effect on her myelopathic pain caused by the spinal cord tumor and syringomyelia.