Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(in print)
ISSN :2433-2410(online)

Creative Commons License
These article are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
number of downloads : ?
Shimane Journal of Medical Science 4 1
1980-06-01 発行

Suppressive Effect of Lactobacillus casei on the Drug Resistance Transfer in Escherichia coli

Saito, Hajime
Tomioka, Haruaki
Asano, Kyoko
Watanabe, Takashi
File
Description
In the mixed culture of Escherichia coli S-58 and S-42 strains, CP^r gene is thought to be transferred from the former to the latter by conjugation. The cultured supernatant of Lactobacillus casei YIT 0003 exhibited a considerable suppressive effect on the drug resistance transfer between the two E. coli strains. However,it failed to inhibit the R-factor transfer between E. coli W 3630 and ML 1410. This factor in the supernatant was heat stable, ethanol-precipitable, and the molecular weight was estimated to be approximately 6,000. This factor probably constitutes a non-dialyzable complex with some other substances in the culture fluid.