Objective: To compare surgical outcomes after combined deep sclerectomy and trabeculotomy （DS-LOT） between primary open-angle glaucoma（POAG） and exfoliation glaucoma （EXG）.
Methods: This retrospective study included 144 consecutive patients with POAG （n=49） or EXG （n=95）who underwent DS-LOT. Surgical failure was defined as the need for additional glaucoma surgeries or two consecutive measurements of postoperative intraocular pressure （IOP） that exceeded the preoperative IOP. The decreases in postoperative IOP and success probabilities were compared in both groups.
Results: Both groups had significant IOP decreases at all follow-up visits to 4 years postoperatively. The preoperative and postoperative IOP levels at 3 and 6 months in the EXG group were signifi cantly higher than in the POAG group.
Conclusions: The postoperative success probabilities in the EXG group were significantly lower than in the POAG group. More preoperative medication use and the absence of combined cataract surgery, rather than EXG itself, were associated with DS-LOT failure.