Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(in print)
ISSN :2433-2410(online)

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Shimane Journal of Medical Science 31 1
2014-12-01 発行

Comparison of Acute Toxicity of ZnO and Silica-coated ZnO Nanoparticles in Mice after Single Intravenous Injection: Preliminary Experiment to Apply to Biological Imaging

Tongu, Miki
Hashimoto, Hideki
Yamada, Takaya
Yasuda Toshihiro
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In the present study, acute toxicity of ZnO NPs and silica-coated ZnO NPs following intravenous injection using mice were evaluated. ZnO dispersion (average size: 148 nm) at a dose of 10 mg/kg and 30 mg/kg, and a Silica-coated ZnO (ZnOSiO2)at a dose of 10 mg/kg, 30 mg/kg and 130 mg/kg were injected intravenously via tail vein of mouse. All mice (n = 6) died within 5 min following intravenous ZnO dose of 10 mg/kg and 30 mg/kg. Impaired motility and convulsion were observed before the death. On the other hand, silica-coating can reduce the toxicity. All mice survived and impaired motility was not observed following intravenous ZnO-SiO2 (average size: 81 nm) treatment at the same dose of ZnO NPs. At a dose of 130 mg/kg, impaired motility and convulsion was observedin all mice, one mouse out of 5 mice died after 5 min. Blood coagulation was observed in all died mice,which may be related to the toxicity of ZnO NPs.