Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(in print)
ISSN :2433-2410(online)

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Shimane Journal of Medical Science 28 2
2012-02-01 発行

Functional Polymorphisms of the Cyclooxygenase-2 Gene and Risk for Chronic Obstructive Pulmonary Disease in Japanese Population

LiJun CHEN
Taooka, Yasuyuki
Ohe, Miki
Takahashi, Hitoshi
Sutani, Akihisa
Kuraki, Takashige
Wang XU
XiaoBo HUANG
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Description
Chronic obstructive pulmonary disease(COPD)is characterized by chronic inflammation. Cyclooxygenase-2(COX-2) plays a very important role in the progress of inflammation. Several potentially functional polymorphisms of the COX-2 gene were identified and proposed to be associated with COPD susceptibility. In this study, we aimed to investigate a possible association between COX-2(-765G>C;-1195G>A) polymorphisms and the risk of COPD in the Japanese population. COX-2 gene polymorphisms were identified by polymerase chain reaction-restriction fragment-length polymorphism(PCRRFLP)
in 103 Japanese patients with COPD and 129 healthy controls. The distributions of genotypes and alleles were compared by using the χ2 test. The odds ratios(OR) and 95% confidence intervals (95%CI) were calculated by a logistic regression analysis. The frequencies of the GG, GC, CC genotypes of COX-2-765G>C and GG, GA, AA genotypes
of COX-2-1195G>A in the COPD group were 94.2%, 5.8%, 0.0% and 14.6%, 40.8%, 44.6%, respectively. These frequencies in control group were 89.1%, 10.9%, 0.0% and 23.3%, 44.9%, 31.8%, respectively. The COX-2-1195AA was more prevalent in the COPD group(44.6%) than the control group (31.8%). The distribution of the -765C was higher
in the control group(5.5%) in comparison to the COPD group(2.9%). In conclusion, the COX-2-1195AA genotype was associated with an increased risk for COPD in the Japanese population.