The intraperitoneal injection of cholate (10 ㎎ per 100 g body weight) to rats elevated the hepatic cyclic AMP levels by 1.5 to 2.0-fold. Furthermore, the hepatic tyrosine aminotransferase was induced by this agent in the both intact and adrenalectomized rats. These data together with previous findings (ref.4) contribute to an understanding of so-called permissive effect produced by glucocorticoids on cyclic AMP mediated process.