Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(in print)
ISSN :2433-2410(online)

Creative Commons License
These article are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
number of downloads : ?
Shimane Journal of Medical Science 15
1997-09-01 発行

Nonimmunologic fetal hydrops and chromosomal disorder : two cases of Down syndrome associated with hematopoietic abnormalities

Masue, Michiya
Miyamoto, Satomi
Inoue, Makoto
Haneda, Noriyuki
Hata, Toshiyuki
Miyazaki, Kohji
Nagasaki, Makoto
Morikawa, Shigeru
Yamaguchi, Seiji
File
Description
We investigated 6 neonates with nonimmunologic fetal hydrops admitted to Shimane Medical University Hospital between 1979 and 1996. Chromosome analysis revealed that two of these neonates (33%) had trisomy 21 (Down syndrome). Our data may suggest the importance of chromosomal analysis of the fetus and the neonate with nonimmunologic fetal hydrops. It was revealed that each of the two neonates with Down syndrome had hematopoietic disorders including pancytopenia and transient abnormal myelopoiesis. Although nonimmunologic fetal hydrops in Down syndrome has often been attributed to the cardiac diseases, hematopoietic disorders should also be considered to be a cause of the fetal hydrops in Down syndrome.