Bulletin of the Faculty of Agriculture, Shimane University

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Bulletin of the Faculty of Agriculture, Shimane University 19
1985-12-20 発行

チアミンアナログの生物活性

The Bioactivities of Thiamine Analogues
Mochida, Kazuo
Nakamura, Toshiie
Ozoe, Yoshihisa
Miyazaki, Hisako
Yokouchi, Takayuki
Saito, Osamu
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Description
The bioactive properties of ten kinds of(2-methyl-4-amino-5-pyrimidinyl) methyl derivatives (Pm derivatives) prepared by the base-exchange reaction of immobilized or free thiaminase I were examined.
The insecticidal and sterilizing activities to housefly and the growth regulating activity to common cutworm were not found. However, the herbicidal activity of Pm-o- aminothiophenol to barnyard grass, the antibacterial activity of Pm-nicotinamide to L. fermentum, and the growth inhibitory activity of Pm-aniline, Pm-quinoline and Pm-piperidine to phytoplankton were found. Particularly, the antialgal activity was excellent and selective : Pm-aniline and Pm-quinoline were effective only to diatoms and Pm-piperidine was effective only to blue algae.