Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21(Cdkn1a) and Pbx1 in Hematopoietic Cells

PLOS ONE 11 巻 7 号 2016-07-7 発行
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タイトル
Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21(Cdkn1a) and Pbx1 in Hematopoietic Cells
著者
Abe Mariko
Pelus Louis M.
Singh Pratibha
Hirade Tomohiro
Purevsuren Jamiyan
Yamaguchi Seiji
収録物名
PLOS ONE
11
7
収録物識別子
ISSN 1932-6203
言語
英語
資源タイプ 学術雑誌論文
出版者
PUBLIC LIBRARY SCIENCE
発行日 2016-07-7
アクセス権 メタデータのみ
関連情報
[DOI] 10.1371/journal.pone.0158290
[PMID] 27387666
備考 Support was provided by: Japan Society for the Promotion of Science [https://www.jsps.go.jp/] grant number 24791063 to MA; National Heart Lung and Blood Institute [http://www.nih.gov/] grant number HL079654 to LP; Japan Society for the Promotion of Science [https://www.jsps.go.jp/] grant number 20390298 to SF; Japan Society for the Promotion of Science [https://www.jsps.go.jp/] grant number 25461593 to SF; Japan Leukemia Research Fund [http://flrf.gr.jp/] to SF; Research Support Funds from the Mochida Memorial Foundation for Medical and Pharmaceutical Research [http://www.mochida.co.jp/zaidan/] to SF; Sankyo Biomedical Research Foundation and the Mitsubishi Pharma Research Foundation [http://www.ds-fdn.or.jp/] to SF; AstraZeneca Research Grant [http://www. astrazeneca.co.jp/] to SF; Naito Foundation [https://www.naito-f.or.jp/jp/index.php] to SF. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.