Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21(Cdkn1a) and Pbx1 in Hematopoietic Cells

PLOS ONE Volume 11 Issue 7 published_at 2016-07-7
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Title
Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21(Cdkn1a) and Pbx1 in Hematopoietic Cells
Creator
Abe Mariko
Pelus Louis M.
Singh Pratibha
Hirade Tomohiro
Purevsuren Jamiyan
Yamaguchi Seiji
Source Title
PLOS ONE
Volume 11
Issue 7
Journal Identifire
ISSN 1932-6203
Language
eng
Resource Type journal article
Publisher
PUBLIC LIBRARY SCIENCE
Date of Issued 2016-07-7
Access Rights metadata only access
Relation
[DOI] 10.1371/journal.pone.0158290
[PMID] 27387666
Remark Support was provided by: Japan Society for the Promotion of Science [https://www.jsps.go.jp/] grant number 24791063 to MA; National Heart Lung and Blood Institute [http://www.nih.gov/] grant number HL079654 to LP; Japan Society for the Promotion of Science [https://www.jsps.go.jp/] grant number 20390298 to SF; Japan Society for the Promotion of Science [https://www.jsps.go.jp/] grant number 25461593 to SF; Japan Leukemia Research Fund [http://flrf.gr.jp/] to SF; Research Support Funds from the Mochida Memorial Foundation for Medical and Pharmaceutical Research [http://www.mochida.co.jp/zaidan/] to SF; Sankyo Biomedical Research Foundation and the Mitsubishi Pharma Research Foundation [http://www.ds-fdn.or.jp/] to SF; AstraZeneca Research Grant [http://www. astrazeneca.co.jp/] to SF; Naito Foundation [https://www.naito-f.or.jp/jp/index.php] to SF. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.