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Shimane Journal of Medical Science Volume 43 Issue 1-2
published_at 2026-06
Patients With Acute Decompensated Heart Failure in an Area With a Super-Aging Society: A Single-Center, Retrospective Cohort Study
SASAKI Hiroyuki
OKAZAKI Kouichi
MAEDA Atsuyoshi
NAKAZAWA Yoshio
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In a super-aging society, the characteristics of acute heart failure (HF) are increasingly shaped by patients of advanced age who are rarely represented in clinical trials. We retrospectively evaluated patients aged ≥18 years hospitalized with acute HF between April 2016 and March 2021 at a single center and classified them as HF with reduced left ventricular ejection fraction (LVEF) (HFrEF, ≤40%) or non-reduced LVEF (HFnon-rEF, >40%). Of 524 admissions, 437 patients were discharged (136 HFrEF, 301 HFnon-rEF). The cohort had a median age of 85 years̶markedly older than typical trial cohorts̶and, overall, patients with HFnon- rEF were older. One-year composite outcomes (HF readmission and cardiovascular death) occurred in 37.7%, with higher rates in HFrEF than in HFnon- rEF (43.8% vs. 34.9%, P = 0.03). One-year all-cause mortality was 19.7%. These event rates exceeded those reported in younger populations, and the use of guideline-directed therapies remained limited. Among patients with HFrEF, the use of ACEI/ ARB, beta-blockers, and MRAs was 61.0%, 72.8%, and 30.9%, respectively. The findings underscore a substantial evidence gap and indicate an increasing need for HF management strategies tailored not only to LVEF but also to patient age, particularly in older adults.
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Faculty of Medicine, Shimane University
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