Background: There are limited reports of follow-up >5 years for lung cancer after minimally invasive surgery. This study examined the 10-year outcomes. Methods: There were 98 eligible patients with pathological stage I non-small cell lung cancer who had undergone video-assisted thoracoscopic surgery lobectomy between 2007 and 2011. Patients’ perioperative factors and clinical course were evaluated retrospectively. Results: Of the patients, 71 had pathological stage IA, and 27 had pathological stage IB. The 10-year overall, relapse-free, and lung cancer- specific survival were 74.4%, 72.4%, and 89.7% for pathological stage IA and 57.4%, 55.9%, and 80.7% for pathological stage IB, respectively. The median time from surgery to recurrence and the diagnosis of second primary lung cancer （SPLC） was 22.0 and 61.0 months, respectively. Conclusion: This study was able to show the 10-year survival outcomes. The incidence of recurrence after 5 years is low in this population. However, it may be necessary to pay attention to SPLC.