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Title Alternative (English)
Visualization of decreased docosahexaenoic acid in the hippocampus of rats fed an n-3 fatty acid-deficient diet by imaging mass spectrometry.
Author
Taira, Shu Japan Advanced Institute of Science and Technology, Ishikawa, Japan
Hashimoto, Michio
Saito, Kazunori Bruker Daltonics K.K., Kanagawa, Japan
Description
The present study employed an imaging mass spectrometry (IMS) method to evaluate the effect of dietary n – 3 fatty acids on the fatty acid composition in rat brain. Rats were divided into two groups and fed either an n – 3 fatty acid-deficient or adequate diet. We determined the decreased n – 3 fatty acids in the hippocampus of rats fed an n – 3 fatty acid-deficient diet compared to the control. IMS visualization was achieved at a resolution of 100 m in rat brain, and showed decreased docosahexaenoic acid (DHA)-containing phosphatidyl choline (PC) or phosphatidyl ethanolamine (PE) in the hippocampus of rats fed an n – 3 fatty acid-deficient diet.
Subject
Docosahexaenoic Acid
Imaging Mass Spectrometry
Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry
Hippocampus
Journal Title
Journal of Biophysical Chemistry
Volume
3
Issue
3
Start Page
221
End Page
226
Published Date
2012-8
DOI
Publisher
Scientific Research Publishing Inc.
NII Type
Journal Article
Text Version
出版社版
Gyoseki ID
e14599
OAI-PMH Set
Faculty of Medicine