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Title Transcription
ニンシン ジュニュウ ボタイ ノ シシツ エイヨウ ガ コ ノ イチガタ トウニョウビョウ ハッショウ ヘ オヨボス エイキョウ
Title Alternative (English)
Maternal intake of essential fatty acid affects development of type 1 diabetes in the offspring
Author
籠橋 有紀子 島根県立大学短期大学部健康栄養学科
Description
Human type 1 diabetes is an autoimmune disease resulting from T-cell-mediated destruction of pancreatic islet beta cells. Maternal environment has been suggested to be important in the development of diabetes. In this study, to investigate the effect of maternal nutrition, in particular the essential fatty acid (EFA) ratio (n-6/n-3) and composition, on the development of type 1 diabetes in the offspring, we prepared different kinds of chows with different n-6/n-3 ratios, and provided them to pregnant and lactating mothers and post-weaning female offspring of non-obese diabetic (NOD) mice, a type 1 diabetes model. The EFA ratio in breast milk and serum of NOD dams became nearly the same as that of the maternal diet. Overt diabetes was not suppressed in the offspring from dams provided with a diet with an n-6/n-3 ratio of 14.5 during gestation and lactation, but it was strongly suppressed in those from dams provided with a diet with an n-6/n-3 ratio of 3.0 during the same period. At 2 and 4 weeks after birth, insulin autoantibodies (IAA) were detected in the offspring from dams provided with a diet with an n-6/n-3 ratio of 14.5, and not detected in those from dams provided with a diet with an n-6/n-3 ratio of 3.0. These findings suggest that n-6/n-3 ratio of the maternal diet during gestation and lactation rather than that of the diet intake by offspring after weaning strongly affects the development of overt diabetes in NOD mice.
Subject
1型糖尿病
NODマウス
母体栄養
必須脂肪酸
膵島炎
Journal Title
Journal of Lipid Nutrition
Volume
22
Issue
1
Start Page
35
End Page
43
ISSN
1343-4594
ISSN(Online)
1883-2237
Published Date
2013
DOI
Publisher
日本脂質栄養学会
Publisher Transcription
ニホン シシツ エイヨウ ガッカイ
Publisher Aalternative
Japan Society for Lipid Nutrition ©
NII Type
Journal Article
Format
PDF
Text Version
出版社版
Gyoseki ID
e17471
OAI-PMH Set
Faculty of Medicine