妊娠・授乳母体の脂質栄養が仔の 1型糖尿病発症へ及ぼす影響

脂質栄養学 22 巻 1 号 35-43 頁 2013 発行
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ファイル情報(添付)
タイトル
妊娠・授乳母体の脂質栄養が仔の 1型糖尿病発症へ及ぼす影響
タイトル
Maternal intake of essential fatty acid affects development of type 1 diabetes in the offspring
タイトル 読み
ニンシン ジュニュウ ボタイ ノ シシツ エイヨウ ガ コ ノ イチガタ トウニョウビョウ ハッショウ ヘ オヨボス エイキョウ
著者
籠橋 有紀子
収録物名
脂質栄養学
Journal of Lipid Nutrition
22
1
開始ページ 35
終了ページ 43
収録物識別子
ISSN 1343-4594
EISSN 1883-2237
内容記述
その他
Human type 1 diabetes is an autoimmune disease resulting from T-cell-mediated destruction of pancreatic islet beta cells. Maternal environment has been suggested to be important in the development of diabetes. In this study, to investigate the effect of maternal nutrition, in particular the essential fatty acid (EFA) ratio (n-6/n-3) and composition, on the development of type 1 diabetes in the offspring, we prepared different kinds of chows with different n-6/n-3 ratios, and provided them to pregnant and lactating mothers and post-weaning female offspring of non-obese diabetic (NOD) mice, a type 1 diabetes model. The EFA ratio in breast milk and serum of NOD dams became nearly the same as that of the maternal diet. Overt diabetes was not suppressed in the offspring from dams provided with a diet with an n-6/n-3 ratio of 14.5 during gestation and lactation, but it was strongly suppressed in those from dams provided with a diet with an n-6/n-3 ratio of 3.0 during the same period. At 2 and 4 weeks after birth, insulin autoantibodies (IAA) were detected in the offspring from dams provided with a diet with an n-6/n-3 ratio of 14.5, and not detected in those from dams provided with a diet with an n-6/n-3 ratio of 3.0. These findings suggest that n-6/n-3 ratio of the maternal diet during gestation and lactation rather than that of the diet intake by offspring after weaning strongly affects the development of overt diabetes in NOD mice.
主題
1型糖尿病
NODマウス
母体栄養
必須脂肪酸
膵島炎
言語
日本語
資源タイプ 学術雑誌論文
出版者
日本脂質栄養学会
Japan Society for Lipid Nutrition ©
発行日 2013
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
関連情報
[DOI] 10.4010/jln.22.35
ニホン シシツ エイヨウ ガッカイ