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language
eng
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Original article
Author
ESUMI, Chika
Description
P57 is known to have anti-tumor activity through inhibition of cyclin-dependent kinases. We performed immunohistochemical analysis on expression of P57 in 92 cases of epithelial ovarian carcinoma (EOC), of which, 31, 14, 18 and 29 were diagnosed as serous, mucinous, endometrioid (EC) and clear cell carcinoma (CCC), respectively. Of 92 cases of EOC, 6 and 28 were positive for P57 in the nucleus and the cytoplasm, respectively. Five cases of 29 CCC (17.2%) were positive in the nucleus, which was significantly greater than in non-CCC (p = 0.03). In contrast, positive cases in the cytoplasm were significantly greater in EC (55.6 and 23.0% for EC and non-EC, respectively, p = 0.01). Expression patterns of nuclear and cytoplasmic p57 showed no correlations with clinical stage of EOC. Clinicopathological significance of P57 expression in EOC would need further investigation.
Subject
epithelial ovarian carcinoma
p57
immunohistochemistry
clear cell carcinoma
endometrioid carcinoma
Journal Title
Shimane Journal of Medical Science
Volume
39
Issue
1
Start Page
33
End Page
39
ISSN
03865959
ISSN(Online)
24332410
Published Date
2022-03
NCID
AA00841586
DOI
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
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出版社版
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Faculty of Medicine
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