| File | |
| language |
eng
|
| Attribute |
Original article
|
| Author |
Qing, YAN
Department of Developmental Biology
Ogawa, Noriko
Department of Developmental Biology
Matsumoto, Akihiro
Department of Developmen
Yuqi, DANG
The Traditional Chinese Medicine Hospital of Yinchuan
Otani, Hiroki
Department of Developmen
|
| Description | Effects of Kampo formulas which have been long
used clinically for obese patients remain unclear at the cellular level. The objective of this study is to investigate the effects of 8 commonly-used Kampos on the differentiation and proinflammatory cytokines expression of 3T3-L1 cells. 3T3-L1 preadipocytes were induced differentiation being treated with test 8 Kampos through the induction period. Oil red O staining and mRNAs expressions of peroxisome proliferator- active receptor-γ （PPARγ） and adiponectin were examined to evaluate effects of the Kampos on the differentiation. Tumor necrosis factor-alpha （TNF-α）, interleukin-6, and monocyte chemoattractant protein-1 （MCP-1） mRNAs were examined to investigate the anti-inflammatory effects of the Kampos. PPARγ and/or adiponectin, as well as MCP-1 and/or TNF-α mRNAs were significantly decreased by Boiogito and a few other Kampos when compared with the control. These results at the cellular level are compatible with the clinical beneficial effects of these Kampos. |
| Subject | 3T3-L1
differentiation
inflammation
PPARγ
MCP-1
|
| Journal Title |
Shimane Journal of Medical Science
|
| Volume | 34
|
| Issue | 3
|
| Start Page | 109
|
| End Page | 118
|
| ISSN | 03865959
|
| ISSN（Online） | 24332410
|
| Published Date | 2018-03-31
|
| NCID | AA00841586
|
| Publisher | Faculty of Medicine, Shimane University
|
| Publisher Aalternative | 島根大学医学部
|
| NII Type |
Departmental Bulletin Paper
|
| Format |
PDF
|
| Rights | Faculty of Medicine, Shimane University
|
| Text Version |
出版社版
|
| Gyoseki ID | e36081
e33157
|
| OAI-PMH Set |
Faculty of Medicine
|
| 他の一覧 |
