ファイル情報(添付) | |
タイトル |
Effects of Kampo Formulas on Differentiation and Proinflammatory Cytokines Expression of 3T3-L1 Cells
|
著者 |
顔 青
小川 典子
毓起 党
|
収録物名 |
Shimane Journal of Medical Science
|
巻 | 34 |
号 | 3 |
開始ページ | 109 |
終了ページ | 118 |
収録物識別子 |
ISSN 03865959
EISSN 24332410
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内容記述 |
抄録・要旨
Effects of Kampo formulas which have been long
used clinically for obese patients remain unclear at the cellular level. The objective of this study is to investigate the effects of 8 commonly-used Kampos on the differentiation and proinflammatory cytokines expression of 3T3-L1 cells. 3T3-L1 preadipocytes were induced differentiation being treated with test 8 Kampos through the induction period. Oil red O staining and mRNAs expressions of peroxisome proliferator- active receptor-γ (PPARγ) and adiponectin were examined to evaluate effects of the Kampos on the differentiation. Tumor necrosis factor-alpha (TNF-α), interleukin-6, and monocyte chemoattractant protein-1 (MCP-1) mRNAs were examined to investigate the anti-inflammatory effects of the Kampos. PPARγ and/or adiponectin, as well as MCP-1 and/or TNF-α mRNAs were significantly decreased by Boiogito and a few other Kampos when compared with the control. These results at the cellular level are compatible with the clinical beneficial effects of these Kampos. |
主題 |
3T3-L1
differentiation
inflammation
PPARγ
MCP-1
|
言語 |
英語
|
資源タイプ | 紀要論文 |
出版者 |
Faculty of Medicine, Shimane University
島根大学医学部
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発行日 | 2018-03-31 |
権利情報 |
Faculty of Medicine, Shimane University
|
出版タイプ | Version of Record(出版社版。早期公開を含む) |
アクセス権 | オープンアクセス |
関連情報 |
[NCID] AA00841586
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