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language
eng
Attribute
Original Article
Author
Fukuyama, Chika
Izumi, Daisuke
Ishikawa, Nahoko
Oka, Akihiko
Mishiro, Tomoko
ISHIHARA, Shunji Department of Internal Medicine II, Shimane University Faculty of Medicine
Adachi, Kiyoichi
Description
Background
Celiac disease is a chronic autoimmune enteropathy caused by gluten ingestion. While its prevalence in Western countries is reported to be as high as 1%, the prevalence has not been evaluated in a large-scale study of a Japanese population. The aim of our study was to clarify the possible presence of celiac disease in a Japanese non-clinical population as well as in patients showing symptoms suggestive of the disease.

Methods
Serum samples were collected from 2008 non-clinical adults and 47 patients with chronic unexplained abdominal symptoms between April 2014 and June 2016. The anti-tissue transglutaminase (TTG) immunoglobulin A antibody titer was determined as a screening test for celiac disease in all subjects, and individuals with a value of >2 U/mL subsequently underwent testing for the presence of serum endomysial IgA antibody (EMA) as confirmation. Those testing positive for EMA or with a high concentration (>10 U/mL) of TTG were further investigated by histopathological examinations of duodenal mucosal biopsy specimens and HLA typing tests.

Results
Of the 2008 non-clinical adults from whom serum samples were collected, 161 tested positive for TTG, and all tested negative for EMA. Four subjects who had a high TTG titer were invited to undergo confirmatory testing, and the histopathological results confirmed the presence of celiac disease in only a single case (0.05%). Of the 47 symptomatic patients, one (2.1%) was found to have a high TTG titer and was diagnosed with celiac disease based on duodenal histopathological findings.

Conclusion
The presence of celiac disease in a non-clinical Japanese population was low at 0.05% and was rarely found in patients with unexplained chronic abdominal symptoms.
Journal Title
Journal of Gastroenterology
Volume
53
Issue
2
Start Page
208
End Page
214
ISSN
0944-1174
ISSN(Online)
1435-5922
Published Date
2017-4-7
DOI
Publisher
シュプリンガー・ジャパン(株)
NII Type
Journal Article
Format
PDF
Text Version
出版社版
Gyoseki ID
e34597
e34048
e31062
e34482
OAI-PMH Set
Faculty of Medicine
Remark
日本消化器病学会