言語 |
英語
|
属性 |
Original Article
|
著者 |
Fukuyama, Chika
Izumi, Daisuke
Ishikawa, Nahoko
Oka, Akihiko
Mishiro, Tomoko
石原 俊治
医学部内科学講座内科学第二
足立 経一
|
内容記述(抄録等) | Background
Celiac disease is a chronic autoimmune enteropathy caused by gluten ingestion. While its prevalence in Western countries is reported to be as high as 1%, the prevalence has not been evaluated in a large-scale study of a Japanese population. The aim of our study was to clarify the possible presence of celiac disease in a Japanese non-clinical population as well as in patients showing symptoms suggestive of the disease. Methods Serum samples were collected from 2008 non-clinical adults and 47 patients with chronic unexplained abdominal symptoms between April 2014 and June 2016. The anti-tissue transglutaminase (TTG) immunoglobulin A antibody titer was determined as a screening test for celiac disease in all subjects, and individuals with a value of >2 U/mL subsequently underwent testing for the presence of serum endomysial IgA antibody (EMA) as confirmation. Those testing positive for EMA or with a high concentration (>10 U/mL) of TTG were further investigated by histopathological examinations of duodenal mucosal biopsy specimens and HLA typing tests. Results Of the 2008 non-clinical adults from whom serum samples were collected, 161 tested positive for TTG, and all tested negative for EMA. Four subjects who had a high TTG titer were invited to undergo confirmatory testing, and the histopathological results confirmed the presence of celiac disease in only a single case (0.05%). Of the 47 symptomatic patients, one (2.1%) was found to have a high TTG titer and was diagnosed with celiac disease based on duodenal histopathological findings. Conclusion The presence of celiac disease in a non-clinical Japanese population was low at 0.05% and was rarely found in patients with unexplained chronic abdominal symptoms. |
掲載誌名 |
Journal of Gastroenterology
|
巻 | 53
|
号 | 2
|
開始ページ | 208
|
終了ページ | 214
|
ISSN | 0944-1174
|
ISSN(Online) | 1435-5922
|
発行日 | 2017-4-7
|
DOI | |
出版者 | シュプリンガー・ジャパン(株)
|
資料タイプ |
学術雑誌論文
|
ファイル形式 |
PDF
|
著者版/出版社版 |
出版社版
|
業績ID | e34597
e34048
e31062
e34482
|
部局 |
医学部
|
備考 | 日本消化器病学会
|