File
language
eng
Author
Kawaguchi, Mikiko
Koshimura, Kunio
Murakami, Yoshio
Tsumori, Michihiro
Kato, Yuzuru
Description
It has been reported that insulin treatment improves hypertension in the patients with diabetes mellitus. The mechanisms of the antihypertensive effect of insulin, however, remains to be fully elucidated. Nitric oxide (NO) is generated in the endothelial cells and tonically regulates blood pressure. In the present study, we investigated the effect of insulin on NO production in cultured human endothelial cells. Insulin (1μM, 10μM and lOOμM) increased NO metabolite (N02-) levels in the medium and NO synthase (NOS) activity in cultured human endothelial cells. Insulin also stimulated proliferation and mitogen-associated protein kinase activity of the endothelial cells. These findings suggest that insulin reduces blood pressure by stimulating NO production in the endothelial cells, possibly via induction of NOS molecule and proliferation of endothelial cells.
Journal Title
Shimane journal of medical science
Volume
17
Issue
1
Start Page
9
End Page
13
ISSN
03865959
ISSN(Online)
24332410
Published Date
1999-06-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html