ファイル
言語
英語
著者
川口 美喜子
Koshimura, Kunio
Murakami, Yoshio
Tsumori, Michihiro
Kato, Yuzuru
内容記述(抄録等)
It has been reported that insulin treatment improves hypertension in the patients with diabetes mellitus. The mechanisms of the antihypertensive effect of insulin, however, remains to be fully elucidated. Nitric oxide (NO) is generated in the endothelial cells and tonically regulates blood pressure. In the present study, we investigated the effect of insulin on NO production in cultured human endothelial cells. Insulin (1μM, 10μM and lOOμM) increased NO metabolite (N02-) levels in the medium and NO synthase (NOS) activity in cultured human endothelial cells. Insulin also stimulated proliferation and mitogen-associated protein kinase activity of the endothelial cells. These findings suggest that insulin reduces blood pressure by stimulating NO production in the endothelial cells, possibly via induction of NOS molecule and proliferation of endothelial cells.
掲載誌名
Shimane journal of medical science
17
1
開始ページ
9
終了ページ
13
ISSN
03865959
ISSN(Online)
24332410
発行日
1999-06-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html