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language
eng
Author
Van Roon Anne-Marie M. MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
Oubridge Chris MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
Sposito Benedetta MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
Newman Andrew J. MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
Seraphin Bertrand Equipe Labellisée La Ligue, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS) UMR 7104/Institut National de la Santé et de la Recherche Médicale (INSERM), U964/Université de Strasbourg, 67404 Illkirch, France
Nagai Kiyoshi MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
Subject
splicing; U2 snRNP; SF3b; RNA binding; RRM
Journal Title
RNA
Volume
23
Issue
6
Start Page
968
End Page
981
ISSN
1355-8382
ISSN(Online)
1469-9001
Published Date
2017-06
DOI
PubMed ID
Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
NII Type
Journal Article
OAI-PMH Set
Faculty of Medicine
Remark
We thank Yasushi Kondo for collecting data on the RRM1-Cusl (290-368)p complex crystals and LMB mass spectrometry facility for MALDI-TOF analysis of proteolytic fragments, Dr. Stephen McLaughlin for helping with fluorescence anisotropy data analysis, and the staff at Diamond Light Source beamline 102 and European Synchrotron Radiation Facility beamline ID14-3 for their assistance. We also thank Elena Conti and Sebastian Falk for communicating their unpublished results. We are grateful to Lisa Strittmatter and Pei-chun Lin for critical reading of the manuscript. This project was supported by the Medical Research Council (MC_U105184330), a Wellcome Trust Travelling fellowship, and an MRC career development fellowship (E.O.). B.Sp. was supported by Humanitas Research Foundation. B.Se. was supported by the CNRS, the CERBM-IGBMC and INSERM, the grant ANR-10LABX-0030-INRT, a French State fund managed by the Agence Nationale de la Recherche under the frame program Investissements d'Avenir ANR-10-IDEX-0002-02, and the Ligue Contre le Cancer (Equipe Labellisee 2014).