Phosphoinositide 3-Kinase P110 delta-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation

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Use this link to cite this item : https://ir.lib.shimane-u.ac.jp/52883

language	eng
Author	Akihiko, Oka MISHIMA, Yoshiyuki Department of Internal Medicine II, Shimane University Faculty of Medicine Liu Bo Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Herzog Jeremy W. Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Steinbach Erin C. Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA　/　Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Kobayashi, Taku Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA　/　Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo 108-8642, Japan Plevy Scott E. Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA　/　 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA　/　Synlogic Therapeutics, Boston, MA 02139, USA Sartor R. Balfour Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA　/　 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Subject	PI3K delta; inflammatory bowel diseases; regulatory B cells; IL-10; residential microbiota
Journal Title	CELLS
Volume	8
Issue	10
ISSN（Online）	2073-4409
Published Date	2019-10
DOI	10.3390/cells8101121
PubMed ID	31546615
Publisher	MDPI
NII Type	Journal Article
OAI-PMH Set	Faculty of Medicine
Remark	This research was funded by National Institute of Health, R01DK53347, P01DK094779 and P30DK34987.