Phosphoinositide 3-Kinase P110 delta-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation

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言語	英語
著者	岡明彦三島義之医学部内科学講座内科学第二 Liu Bo Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Herzog Jeremy W. Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Steinbach Erin C. Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA　/　Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Kobayashi, Taku Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA　/　Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo 108-8642, Japan Plevy Scott E. Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA　/　 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA　/　Synlogic Therapeutics, Boston, MA 02139, USA Sartor R. Balfour Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA　/　 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
主題	PI3K delta; inflammatory bowel diseases; regulatory B cells; IL-10; residential microbiota
掲載誌名	CELLS
巻	8
号	10
ISSN（Online）	2073-4409
発行日	2019-10
DOI	10.3390/cells8101121
PubMed ID	31546615
出版者	MDPI
資料タイプ	学術雑誌論文
部局	医学部
備考	This research was funded by National Institute of Health, R01DK53347, P01DK094779 and P30DK34987.