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language
eng
Author
Hashimoto, Michio
Shahdat Hossain Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Ohno, Miho Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Shimane 696-0001, Japan
Kato , Setsushi Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Shimane 696-0001, Japan
Katakura, Masanori
Description
Oxidized low-density lipoprotein (Ox-LDL) is known to be highly atherogenic. Thus, decreasing the blood levels of Ox-LDL through dietary means is an important approach to reduce cardiovascular events in high-risk individuals. In this randomized placebo-controlled human interventional trial, we aimed to evaluate whether Perilla frutescens leaf powder (PLP) ameliorates Ox-LDL and home blood pressure, along with its biological antioxidant potential. Healthy Japanese volunteers aged 30-60 years (n = 60) were randomized to PLP and placebo groups. The PLP group consumed PLP dried using a microwave under reduced pressure, and the placebo group consumed pectin fiber daily for 6 months. Home blood pressure, serum biochemical parameters, and fatty acid profiles of erythrocyte plasma membranes were analyzed. Plasma Ox-LDL levels significantly decreased in the PLP group but not in the placebo group. Mean changes in the biological antioxidant potential and alpha-linolenic acid levels in the erythrocyte plasma membrane were significantly increased in the PLP group than in the placebo group. In subjects with prehypertension (systolic blood pressure [SBP] ³ 120 mmHg), the mean reduction in morning or nocturnal SBP was significantly greater in the PLP group than in the placebo group. Thus, PLP intake may be an effective intervention to prevent cardiovascular diseases.
Subject
Perilla frutescens
a-linolenic acid
atherosclerosis
biological antioxidative potential
oxidized low-density lipoprotein
systolic blood pressure.
Journal Title
Molecules
Volume
25
Issue
9
ISSN
1420-3049
Published Date
2020-4-30
DOI
PubMed ID
Publisher
MDPI
NII Type
Journal Article
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine