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language
eng
Author
Saeki, Takao
Katagiri, Yoshihiro
Narita, Kenichi
Omura, Naoyuki
Description
We developed a method for the determination of γ-aminobutyric acid (GABA) in brain tissue using a gas-liquid chromatograph equipped with a flame ionization detector. This method is based on the formation of a GABA derivative by treatment with isobutyloxycarbonyl chloride and diazomethane, under mild conditions. This method proved to be useful for the determination of GABA in the whole mouse brain. We thus studied the effect of nitrazepam, one of the benzodiazepines (BDZs), on the GABA levels in the mouse brain and found that the concentration of GABA in the nitrazepam treated group was decreased markedly compared with values in the untreated controls.
Subject
gas-liquid chromatography
GABA
mouse brain
Journal Title
Shimane journal of medical science
Volume
6
Issue
1
Start Page
13
End Page
20
ISSN
03865959
ISSN(Online)
24332410
Published Date
1982-06-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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