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language
eng
Author
Kurioka, Soichi
Description
Objective: To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.
Methods: A cross-sectional cohort study.
Results: In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).
Conclusions: Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.
Subject
Diabetes
hyaluronan
vascular function
Journal Title
Biomarkers
Volume
19
Issue
6
Start Page
493
End Page
497
ISSN
1354750X
Published Date
2014-09
DOI
DOI Date
2017-03-23
PubMed ID
NCID
AA11091761
Publisher
Taylor & Francis
NII Type
Journal Article
Format
PDF
Rights
© Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in "Biomarkers" on 2014-09, available online: http://www.tandfonline.com/10.3109/1354750X.2014.940502.
Text Version
著者版
Gyoseki ID
e26993
e27254
e27336
OAI-PMH Set
Faculty of Medicine
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