| ファイル情報(添付) | |
| タイトル |
Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes
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| 著者 |
Kurioka Soichi
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| 収録物名 |
Biomarkers
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| 巻 | 19 |
| 号 | 6 |
| 開始ページ | 493 |
| 終了ページ | 497 |
| 収録物識別子 |
ISSN 1354750X
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| 内容記述 |
その他
Objective: To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.
その他
Methods: A cross-sectional cohort study.
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Results: In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).
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Conclusions: Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.
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| 主題 |
Diabetes
hyaluronan
vascular function
|
| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Taylor & Francis
|
| 発行日 | 2014-09 |
| 権利情報 |
© Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in "Biomarkers" on 2014-09, available online: http://www.tandfonline.com/10.3109/1354750X.2014.940502.
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| 出版タイプ | Accepted Manuscript（出版雑誌の一論文として受付されたもの。内容とレイアウトは出版社の投稿様式に沿ったもの） |
| アクセス権 | オープンアクセス |
| 関連情報 |
[DOI] 10.3109/1354750X.2014.940502
[PMID] 25019422
[NCID] AA11091761
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