| File | |
| Title |
Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes
|
| Creator |
Kurioka Soichi
|
| Source Title |
Biomarkers
|
| Volume | 19 |
| Issue | 6 |
| Start Page | 493 |
| End Page | 497 |
| Journal Identifire |
ISSN 1354750X
|
| Descriptions |
Objective: To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.
Methods: A cross-sectional cohort study.
Results: In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).
Conclusions: Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.
|
| Subjects |
Diabetes
hyaluronan
vascular function
|
| Language |
eng
|
| Resource Type | journal article |
| Publisher |
Taylor & Francis
|
| Date of Issued | 2014-09 |
| Rights |
© Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in "Biomarkers" on 2014-09, available online: http://www.tandfonline.com/10.3109/1354750X.2014.940502.
|
| Publish Type | Accepted Manuscript |
| Access Rights | open access |
| Relation |
[DOI] 10.3109/1354750X.2014.940502
[PMID] 25019422
[NCID] AA11091761
|
