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language
eng
Attribute
original article
Author
Sui Hong
Yamamoto Akira
Uemura, Tomochika
Okunishi, Hideki
Naora, Kohji
Description
The seeds of fenugreek(Trigonella foenumgraecum L.), which have a long history for use in traditional Chinese medicine, are reported to possess some hypocholesterolemic effect. To clarify the mechanism for cholesterol-lowering action, effects of fenugreek on the function and mRNA expression of intestinal cholesterol transporters, Niemann-Pick C1-Like 1(NPC1L1)and ATP binding cassette(ABC)transporters: ABCA1, ABCG5, and ABCG8, were examined in Caco-2 cells. Fenugreek seed water extract significantly inhibited both the net transport of cholesterol from the apical to basolateral side and the accumulation into the cells. Significant suppression in mRNA expression of the cholesterol transporters NPC1L1, ABCA1, ABCG5, ABCG8 and the transcription factor liver X receptor was observed in the cells treated with fenugreek. These results suggest that fenugreek possibly has inhibitory effectson mRNA expression and transport activity of the active cholesterol transporters, leading to the decreased net absorption of cholesterol from the intestine.
Subject
Fenugreek seeds
Caco-2 cells
cholesterol transporter
intestinal absorption
Journal Title
Shimane journal of medical science
Volume
29
Issue
1
Start Page
13
End Page
21
ISSN
03865959
ISSN(Online)
24332410
Published Date
2012-12-01
NCID
AA00841586
Publisher
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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