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ファイル
言語
英語
属性
原著論文
著者
Sui Hong
Yamamoto Akira
上村 智哉
奥西 秀樹
直良 浩司
内容記述(抄録等)
The seeds of fenugreek(Trigonella foenumgraecum L.), which have a long history for use in traditional Chinese medicine, are reported to possess some hypocholesterolemic effect. To clarify the mechanism for cholesterol-lowering action, effects of fenugreek on the function and mRNA expression of intestinal cholesterol transporters, Niemann-Pick C1-Like 1(NPC1L1)and ATP binding cassette(ABC)transporters: ABCA1, ABCG5, and ABCG8, were examined in Caco-2 cells. Fenugreek seed water extract significantly inhibited both the net transport of cholesterol from the apical to basolateral side and the accumulation into the cells. Significant suppression in mRNA expression of the cholesterol transporters NPC1L1, ABCA1, ABCG5, ABCG8 and the transcription factor liver X receptor was observed in the cells treated with fenugreek. These results suggest that fenugreek possibly has inhibitory effectson mRNA expression and transport activity of the active cholesterol transporters, leading to the decreased net absorption of cholesterol from the intestine.
主題
Fenugreek seeds
Caco-2 cells
cholesterol transporter
intestinal absorption
掲載誌名
Shimane journal of medical science
29
1
開始ページ
13
終了ページ
21
ISSN
03865959
ISSN(Online)
24332410
発行日
2012-12-01
NCID
AA00841586
出版者
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
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