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Description
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Medetomidine (MED), midazolam (MID), and butorphanol (BUT) mixed anesthetic (MMB) has been used in laboratory animals since ketamine (KET) was designated as a narcotic in Japan in 2007. We previously reported that MMB produced anesthetic effects in mice and rats. We also demonstrated the efficacy of atipamezole (ATI), an antagonist of MED produced a quick recovery from anesthesia. Anesthetics have various anesthetic effects among different animal species. However, there is little information regarding its effects in rabbits. In the present study, we examined anesthetic effects of MMB compared to KET and xylazine mixed anesthetic (KX). We examined the antagonistic effects of ATI by intramuscular (IM) or intravenous (IV) injection in rabbits. We used the anesthetic score to measure surgical anesthetic duration and recovery time from anesthesia. During the experiments, we measured heart rate, respiratory rate, O2-saturation, and blood pressure. We found there were no significant differences in anesthetic duration and recovery time between MMB and KX. There were no significant differences in heart rate after administration of MMB or KX. Systolic blood pressure at 10 min after administration of MMB was higher than that of KX. The antagonistic effect of ATI by IV injection worked faster than that by IM injection. Overall, MMB is a useful drug that can induce similar anesthetic effects to KX and has an antagonist of ATI that makes rabbits quickly recover from anesthesia. These results may contribute to the welfare of laboratory animals, especially rabbits.
Subject
anesthetic mixture
antagonist
blood pressure
ketamine
rabbits
Journal Title
Experimental Animals
Volume
68
Issue
4
Start Page
443
End Page
452
ISSN
1341-1357
ISSN(Online)
1881-7122
Published Date
2019-11-06
DOI
Publisher
公益社団法人 日本実験動物学会
Publisher Transcription
コウエキ ザイダン ホウジン ニホン ジッケン ドウブツ ガッカイ
Publisher Aalternative
Japanese Association for Laboratory Animal Science
NII Type
Journal Article
Format
PDF
Relation
Text Version
出版社版
Gyoseki ID
e35968
OAI-PMH Set
Faculty of Medicine
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