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language
eng
Attribute
Original article
Author
Qing, YAN Department of Developmental Biology
Ogawa, Noriko Department of Developmental Biology
Matsumoto, Akihiro Department of Developmen
Yuqi, DANG The Traditional Chinese Medicine Hospital of Yinchuan
Otani, Hiroki Department of Developmen
Description
Effects of Kampo formulas which have been long
used clinically for obese patients remain unclear at
the cellular level. The objective of this study is to
investigate the effects of 8 commonly-used Kampos
on the differentiation and proinflammatory cytokines
expression of 3T3-L1 cells. 3T3-L1 preadipocytes
were induced differentiation being treated with test
8 Kampos through the induction period. Oil red O
staining and mRNAs expressions of peroxisome proliferator-
active receptor-γ (PPARγ) and adiponectin
were examined to evaluate effects of the Kampos
on the differentiation. Tumor necrosis factor-alpha
(TNF-α), interleukin-6, and monocyte chemoattractant
protein-1 (MCP-1) mRNAs were examined to
investigate the anti-inflammatory effects of the Kampos.
PPARγ and/or adiponectin, as well as MCP-1
and/or TNF-α mRNAs were significantly decreased
by Boiogito and a few other Kampos when compared
with the control. These results at the cellular
level are compatible with the clinical beneficial effects
of these Kampos.
Subject
3T3-L1
differentiation
inflammation
PPARγ
MCP-1
Journal Title
Shimane Journal of Medical Science
Volume
34
Issue
3
Start Page
109
End Page
118
ISSN
03865959
ISSN(Online)
24332410
Published Date
2018-03-31
NCID
AA00841586
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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