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language
eng
Attribute
original article
Author
Shimbori, Chiko
Shiota, Naotaka
Okunishi, Hideki
Description
Mayumi-Emphysema (ME) mice, which develop spontaneous pulmonary emphysema, were established from wild type C57BL/6J mice. ME mice showed air space enlargement from 2 weeks of age and rapidly developed severe emphysema. The mean linear intercept of the lungs in ME mice was higher than that in control mice at the age of 2 weeks and increased progressively with age in ME mice. However, there was no infiltration of inflammatory cells into the interstitium or alveolar air spaces in the lungs of ME mice. The serum α1-antitrypsin protein level was slightly decreased in ME mice at 4 weeks of age. In ME mice, lung destruction was not associated with an inflammatory reaction, and a slight decrease in serum α1-antitrypsin may be insufficient to induce severe emphysema in ME mice. Hereditary impairment of the normal developmental mechanism for alveoli in the early stage and an abnormal lung structure may induce spontaneous pulmonary emphysema in ME mice.
Subject
naturally occurring emphysema
mice model
C57BL/6 background
Journal Title
Shimane journal of medical science
Volume
32
Issue
1
Start Page
19
End Page
26
ISSN
03865959
ISSN(Online)
24332410
Published Date
2015-09-01
NCID
AA00841586
Publisher
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
Gyoseki ID
e28058
OAI-PMH Set
Faculty of Medicine
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