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ファイル
言語
英語
属性
原著論文
著者
新堀 智子
塩田 直孝
新林 友美
奥西 秀樹
内容記述(抄録等)
Mayumi-Emphysema (ME) mice, which develop spontaneous pulmonary emphysema, were established from wild type C57BL/6J mice. ME mice showed air space enlargement from 2 weeks of age and rapidly developed severe emphysema. The mean linear intercept of the lungs in ME mice was higher than that in control mice at the age of 2 weeks and increased progressively with age in ME mice. However, there was no infiltration of inflammatory cells into the interstitium or alveolar air spaces in the lungs of ME mice. The serum α1-antitrypsin protein level was slightly decreased in ME mice at 4 weeks of age. In ME mice, lung destruction was not associated with an inflammatory reaction, and a slight decrease in serum α1-antitrypsin may be insufficient to induce severe emphysema in ME mice. Hereditary impairment of the normal developmental mechanism for alveoli in the early stage and an abnormal lung structure may induce spontaneous pulmonary emphysema in ME mice.
主題
naturally occurring emphysema
mice model
C57BL/6 background
掲載誌名
Shimane journal of medical science
32
1
開始ページ
19
終了ページ
26
ISSN
03865959
ISSN(Online)
24332410
発行日
2015-09-01
NCID
AA00841586
出版者
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e28058
部局
医学部
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