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language
jpn
Attribute
original article
Author
LiJun CHEN
Taooka, Yasuyuki
Ohe, Miki
Takahashi, Hitoshi
Sutani, Akihisa
Kuraki, Takashige
Wang XU
XiaoBo HUANG
Description
Chronic obstructive pulmonary disease(COPD)is characterized by chronic inflammation. Cyclooxygenase-2(COX-2) plays a very important role in the progress of inflammation. Several potentially functional polymorphisms of the COX-2 gene were identified and proposed to be associated with COPD susceptibility. In this study, we aimed to investigate a possible association between COX-2(-765G>C;-1195G>A) polymorphisms and the risk of COPD in the Japanese population. COX-2 gene polymorphisms were identified by polymerase chain reaction-restriction fragment-length polymorphism(PCRRFLP)
in 103 Japanese patients with COPD and 129 healthy controls. The distributions of genotypes and alleles were compared by using the χ2 test. The odds ratios(OR) and 95% confidence intervals (95%CI) were calculated by a logistic regression analysis. The frequencies of the GG, GC, CC genotypes of COX-2-765G>C and GG, GA, AA genotypes
of COX-2-1195G>A in the COPD group were 94.2%, 5.8%, 0.0% and 14.6%, 40.8%, 44.6%, respectively. These frequencies in control group were 89.1%, 10.9%, 0.0% and 23.3%, 44.9%, 31.8%, respectively. The COX-2-1195AA was more prevalent in the COPD group(44.6%) than the control group (31.8%). The distribution of the -765C was higher
in the control group(5.5%) in comparison to the COPD group(2.9%). In conclusion, the COX-2-1195AA genotype was associated with an increased risk for COPD in the Japanese population.
Journal Title
Shimane journal of medical science
Volume
28
Issue
2
Start Page
69
End Page
74
ISSN
03865959
ISSN(Online)
24332410
Published Date
2012-02-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
Gyoseki ID
e16745
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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