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Takeuchi Fumihiko Medical Genomics Center, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan
Akiyama Masato These authors contributed equally: Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara. Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan
Matoba Nana These authors contributed equally: Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara. Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan
Katsuya Tomohiro Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan
Nakatochi Masahiro Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, 466-8560, Japan
Tabara Yasuharu Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan
Narita Akira Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan
Saw Woei-Yuh Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore
Moon Sanghoon Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea
Spracklen Cassandra N. Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA
Chai Jin-Fang Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore
Kim Young-Jin Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea
Zhang Liang Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore
Wang Chaolong Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore Duke-NUS Medical School, Singapore, 169857, Singapore Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Li Huaixing CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Li Honglan State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China
Wu Jer-Yuarn Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan School of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan
Dorajoo Rajkumar Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore
Nierenberg Jovia L. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
Wang Ya Xing Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China
He Jing Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA
Bennett Derrick A. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Takahashi Atsushi Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, 565-0873, Japan
Momozawa Yukihide Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan
Hirata Makoto Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan
Matsuda Koichi Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, 277-8561, Japan
Rakugi Hiromi Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan
Nakashima Eitaro Division of Endocrinology and Diabetes, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan Department of Diabetes and Endocrinology, Chubu Rosai Hospital, Nagoya, 455-8530, Japan
Isono Masato Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan
Shirota Matsuyuki Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan
Hozawa Atsushi Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan
Ichihara Sahoko Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan
Matsubara Tatsuaki Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, 470-0195, Japan
Yamamoto Ken Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, 830-0011, Japan
Kohara Katsuhiko Faculty of Collaborative Regional Innovation, Ehime University, Matsuyama, 790-8577, Ehime, Japan
Igase Michiya Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, 791-0295, Ehime, Japan
Han Sohee Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea
Gordon-Larsen Penny Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
Huang Wei Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI), Shanghai, 201203, China
Lee Nanette R. USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, 6000, Philippines Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, 6000, Philippines
Adair Linda S. Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
Hwang Mi Yeong Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea
Lee Juyoung Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea
Chee Miao Li Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore
Sabanayagam Charumathi Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore
Zhao Wanting Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore Duke-NUS Medical School, Singapore, 169857, Singapore
Liu Jianjun Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
Reilly Dermot F. Merck Sharp Dohme Corp, Kenilworth, NJ 07033, USA
Sun Liang CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Huo Shaofeng CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Edwards Todd L. Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA
Long Jirong Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA
Chang Li-Ching Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan
Chen Chien-Hsiun Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan
Yuan Jian-Min Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, PA 15232, USA
Koh Woon-Puay Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore Health Services and Systems Research, Duke-NUS Medical School, Singapore, 169857, Singapore
Friedlander Yechiel Unit of Epidemiology, Hebrew University-Hadassah Braun School of Public Health, Jerusalem, P.O. Box 12272, Israel
Kelly Tanika N. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
Wei Wen Bin Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China
Xu Liang Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China
Cai Hui Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA
Xiang Yong-Bing State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China
Lin Kuang Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Clarke Robert Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Walters Robin G. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Millwood Iona Y. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Li Liming Chinese Academy of Medical Sciences, Beijing, 100006, China Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China
Chambers John C. Department of Epidemiology and Biostatistics, Imperial College London, London, SW7 2AZ, UK
Kooner Jaspal S. National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK
Elliott Paul Medical Research Council-Public Health England (MRC-PHE) Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK Imperial College Biomedical Research Centre, Imperial College London, London, SW7 2AZ, UK UK-Dementia Research Institute at Imperial College London, London, SW7 2AZ, UK National Institute for Health Research (NIHR) Health Protection Research Unit on Health Impacts of Environmental Hazards, London, SW7 2AZ, UK Health Data Research UK-London, London, UK
van der Harst Pim Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, Netherlands
Chen Zhengming Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Sasaki Makoto Iwate Tohoku Medical Megabank Organization, Iwate, 028-3694, Japan
Shu Xiao-Ou Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA
Jonas Jost B. Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Germany, Mannheim, 68167, Germany
He Jiang Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, LA, USA
Heng Chew-Kiat Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, Singapore, 119228, Singapore
Chen Yuan-Tsong Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan
Zheng Wei Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA
Lin Xu CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Teo Yik-Ying Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, 119077, Singapore
Tai E-Shyong Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore Duke-NUS Medical School, Singapore, 169857, Singapore Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
Cheng Ching-Yu Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore
Wong Tien Yin Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore
Sim Xueling Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore
Mohlke Karen L. Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA
Yamamoto Masayuki Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan
Kim Bong-Jo Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea
Miki Tetsuro Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, 791-0295, Ehime, Japan
Yokota Mitsuhiro Department of Genome Science, School of Dentistry, Aichi Gakuin University, Nagoya, 464-8650, Japan
Kamatani Yoichiro Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan
Kubo Michiaki RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan
Kato Norihiro Medical Genomics Center, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan
Journal Title
NATURE COMMUNICATIONS
Volume
9
ISSN
2041-1723
Published Date
2018-11-28
DOI
PubMed ID
Publisher
NATURE PUBLISHING GROUP
NII Type
Journal Article
OAI-PMH Set
Faculty of Medicine
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