| File | |
| language |
eng
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| Author |
Kurioka, Soichi
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| Description | Objective: To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.
Methods: A cross-sectional cohort study.
Results: In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).
Conclusions: Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.
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| Subject | Diabetes
hyaluronan
vascular function
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| Journal Title |
Biomarkers
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| Volume | 19
|
| Issue | 6
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| Start Page | 493
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| End Page | 497
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| ISSN | 1354750X
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| Published Date | 2014-09
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| DOI | |
| DOI Date | 2017-03-23
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| PubMed ID | |
| NCID | AA11091761
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| Publisher | Taylor & Francis
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| NII Type |
Journal Article
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| Format |
PDF
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| Rights | © Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in "Biomarkers" on 2014-09, available online: http://www.tandfonline.com/10.3109/1354750X.2014.940502.
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| Text Version |
著者版
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| Gyoseki ID | e26993
e27254
e27336
|
| OAI-PMH Set |
Faculty of Medicine
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