KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1 beta from PBMCs in a patient with Muckle-Wells syndrome

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language	eng
Author	Kaneko, Naoe Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan Kurata, Mie Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan Yamamoto, Toshihiro Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan Shigemura, Tomonari Department of Pediatrics, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan Agematsu, Kazunaga Department of Pediatrics, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan Yamazaki , Takashi Takeda, Hiroyuki Department of Pediatrics, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan Sawasaki, Tatsuya Division of Cell-Free Sciences, Ehime University Proteo-Science Center, Bunkyocho 3, Matsuyama, Ehime, 790-8577, Japan Koga, Tomohiro Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan Kawakami , Atsushi Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan Yachie, Akihiro Division of Medical Safety, Kanazawa University Hospital, Kanazawa, Ishikawa, 920-8641, Japan Migita, Kiyoshi Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan Yoshiura, Koh-ichiro Department of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4, Nagasaki, 852-8523, Japan Urano, Takeshi Masumoto, Junya Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan
Journal Title	SCIENTIFIC REPORTS
Volume	10
Issue	1
ISSN	2045-2322
Published Date	2020-08-11
DOI	10.1038/s41598-020-70513-0
PubMed ID	32782316
Publisher	NATURE PUBLISHING GROUP
NII Type	Journal Article
OAI-PMH Set	Faculty of Medicine
Remark	We thank the Division of Laboratory Animal Research of the Advanced Research Support Center (ADRES), Ehime University for technical assistance. This work was supported by JSPS KAKENHI, Grant Numbers JP17H04656 and JP17K19685 (to J.M.), and JP16H00609, JP17H00599, and JP18H00464 (to N.K.), and by the Center for Clinical and Translational Research of Kyushu University Hospital. This work was also supported by Platform for Drug Discovery, Informatics, and Structural Life Science from Japan Agency for Medical Research and Development (AMED).