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language
eng
Attribute
original article
Author
Sutani, Akihisa
Kosaka, Shinji
Harada, Yuji
Kanda, Hibiki
Kuraki, Takashige
Description
Pleomorphic carcinoma(PC) is a rare tumor that usually has an aggressive clinical course and a poor  prognosis. We investigated the hypothesis that PC overexpresses angiogenic factors. Furthermore, we compared rates of expression of angiogenic factors in PC and adenocarcinoma(AD) of the lung. We collected each 11 cases of PC and AD in which the patients underwent either a lung resection or at autopsy. We immunohistochemically examined the expression of angiogenic factors. Vascular endothelial growth factor(VEGF) and basic-fibroblast growth factor were expressed in many cases of both PC and AD, and there were no significant differences between the
two groups. However, the expression of cyclooxygenase(COX)-2 and hypoxia inducible factor-1α, and the microvessel density, were significantly greater in PC than in AD. These findings suggest that PC was associated with increased angiogenesis and that the
tumor tissue was in a hypoxic state. 
Journal Title
Shimane journal of medical science
Volume
28
Issue
2
Start Page
75
End Page
84
ISSN
03865959
ISSN(Online)
24332410
Published Date
2012-02-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
Gyoseki ID
e16900
e16937
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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