Comprehensive Analysis of TNXB-correlated Expressed Genes in Metastatic Lymphoid Tumor Cells Based on a Bioinformatic Approach

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ファイル情報(添付)
タイトル ( eng )
Comprehensive Analysis of TNXB-correlated Expressed Genes in Metastatic Lymphoid Tumor Cells Based on a Bioinformatic Approach
著者
後藤 孝太
収録物名
Shimane Journal of Medical Science
42
1-2
開始ページ 7
終了ページ 17
収録物識別子
ISSN 03865959
EISSN 24332410
内容記述
抄録・要旨
Analyses of expression levels of tenascin-X gene (TNXB) in primary and metastatic tumor cells from 23 cancer tissues showed that TNXB expression is significantly downregulated in metastatic lymphoid tumor cells. Correlation analysis of TNXB expression with the expression of 19,193 genes in 22 metastatic lymphoid tumor cells showed that 4,654 genes have significant correlated expression. Among genes exhibiting correlated expression with TNXB, 62 genes showed upregulated expression in metastatic lymphoid tumor cells. Metascape analysis of the 62 upregulated genes revealed enrichment of genes related to immune response. TRRUST analysis of the 62 upregulated genes revealed 8 transcription factors with comprehensive transcriptional networks. Among them, STAT1 was predicted to regulate expression of CD40 and CD86, while RELA was predicted to regulate expression of CD40, CD83, CD86, ALOX5 and SLC25A27. Downregulation of TNXB and associated upregulation of these target genes may play a role in certain characteristics of metastatic lymphoid tumor cells.
主題
tenascin-X
primary and metastatic lymphoid tumor cells
DepMap
Metascape
TRRUST
言語
英語
資源タイプ 紀要論文
出版者
Faculty of Medicine, Shimane University
島根大学医学部
発行日 2025-07
権利情報
Faculty of Medicine, Shimane University
権利関係(リンク) Creative Commons License
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
関連情報
[NCID] AA00841586