Comprehensive Analysis of TNXB-correlated Expressed Genes in Metastatic Lymphoid Tumor Cells Based on a Bioinformatic Approach

Abstract

Analyses of expression levels of tenascin-X gene （TNXB） in primary and metastatic tumor cells from 23 cancer tissues showed that TNXB expression is significantly downregulated in metastatic lymphoid tumor cells. Correlation analysis of TNXB expression with the expression of 19,193 genes in 22 metastatic lymphoid tumor cells showed that 4,654 genes have significant correlated expression. Among genes exhibiting correlated expression with TNXB, 62 genes showed upregulated expression in metastatic lymphoid tumor cells. Metascape analysis of the 62 upregulated genes revealed enrichment of genes related to immune response. TRRUST analysis of the 62 upregulated genes revealed 8 transcription factors with comprehensive transcriptional networks. Among them, STAT1 was predicted to regulate expression of CD40 and CD86, while RELA was predicted to regulate expression of CD40, CD83, CD86, ALOX5 and SLC25A27. Downregulation of TNXB and associated upregulation of these target genes may play a role in certain characteristics of metastatic lymphoid tumor cells.