Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance Through the CXCL12/CXCR4/mTOR/TGF beta Signaling Pathway in Breast Cancer Cells

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Use this link to cite this item : https://ir.lib.shimane-u.ac.jp/52799

language	eng
Author	Li Shaolan Department of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan Fan Yang Department of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan Kumagai, Asako Department of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan Kawakita, Emi Department of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan Kitada, Munehiro 1 Department of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan 2 Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan KANASAKI, Keizo Koya, Daisuke 1 Department of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan 2 Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
Subject	DPP-4; EMT; chemoresistance; ABC transporters; apoptosis; breast cancer
Journal Title	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume	21
Issue	3
ISSN（Online）	1422-0067
Published Date	2020-02
DOI	10.3390/ijms21030805
PubMed ID	31991851
Publisher	MDPI
NII Type	Journal Article
OAI-PMH Set	Faculty of Medicine
Remark	Authors declare there is no conflict interest with this study. This study was partially supported by grants from the Japan Society for the Promotion of Science awarded to KK (19K08738) and DK (16K15472). This study was partially supported by a Grant for Promoted Research awarded to KK (K2018-28) from Kanazawa Medical University. S.L. is supported by foreign scholar grants from Kanazawa Medical University. Boehringer Ingelheim (Japan), MitsubishiTanabe Pharma and Ono Pharmaceutical, Taisho Pharmaceutical, Kyowa-Hakko Kirin contributed to establishing the Division of Anticipatory Molecular Food Science and Technology. KK is under a consultancy agreement with Boehringer Ingelheim.