Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance Through the CXCL12/CXCR4/mTOR/TGF beta Signaling Pathway in Breast Cancer Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Volume 21 Issue 3 published_at 2020-02
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Title
Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance Through the CXCL12/CXCR4/mTOR/TGF beta Signaling Pathway in Breast Cancer Cells
Creator
Li Shaolan
Fan Yang
Kumagai Asako
Kawakita Emi
Kitada Munehiro
Koya Daisuke
Source Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21
Issue 3
Journal Identifire
EISSN 1422-0067
Subjects
DPP-4; EMT; chemoresistance; ABC transporters; apoptosis; breast cancer ( Other)
Language
eng
Resource Type journal article
Publisher
MDPI
Date of Issued 2020-02
Access Rights metadata only access
Relation
[DOI] 10.3390/ijms21030805
[PMID] 31991851
Remark Authors declare there is no conflict interest with this study. This study was partially supported by grants from the Japan Society for the Promotion of Science awarded to KK (19K08738) and DK (16K15472). This study was partially supported by a Grant for Promoted Research awarded to KK (K2018-28) from Kanazawa Medical University. S.L. is supported by foreign scholar grants from Kanazawa Medical University. Boehringer Ingelheim (Japan), MitsubishiTanabe Pharma and Ono Pharmaceutical, Taisho Pharmaceutical, Kyowa-Hakko Kirin contributed to establishing the Division of Anticipatory Molecular Food Science and Technology. KK is under a consultancy agreement with Boehringer Ingelheim.