ファイル情報(添付) | |
タイトル |
細胞行動におけるdibutyryl cyclic AMPの影響 : チャイニーズハムスター肺細胞由来のグルコサミン要求変異株に関する研究
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タイトル |
Effects of Dibutyryl Cyclic AMP in Cell Behavior : Studies on Glucosamine-Requiring Mutant Derived from Chinese Hamster Lung Cells
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タイトル 読み |
サイボウ コウドウ ニオケル DIBUTYRYL CYCLIC AMP ノ エイキョウ チャイニーズ ハムスター ハイ サイボウ ユライ ノ グルコサミン ヨウキュウ ヘンイカブ ニ カンスル ケンキュウ
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著者 |
小野田 哲夫
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収録物名 |
島根大学理学部紀要
Memoirs of the Faculty of Science, Shimane University
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巻 | 15 |
開始ページ | 65 |
終了ページ | 74 |
収録物識別子 |
ISSN 03879925
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内容記述 |
抄録・要旨
The effect of dibutyryl adenosine cyclic 3': 5' monophosphate (db-cAMP) on growth, adhesion and motile properties of glucosamine-requiring mutant, G72-8 derived from Chinese hamster lung cells was studied. The properties of the mutant cells, which was characterized by a round morphology and a decreased adhesion, was further emphasized when treated with mannosamine. The mutant cells become spindle shape and look similar to parent cells when treated with db-cAMP, whereas the adhesiveness remains decreased. Further, when the mutant cells cultured with mannosamine was treated with db-cAMP, their cell behaviors showed no significant change in spite of recognizable morphological reversion. The mutant cells showed a slight decrease in the content of cyclic AMP when compared to the parent cells, but no significant differences between the mutant cells grown in presence and absence of N-acetylglucosamine were observed. On the other hand, N-acetylglucosamine restored to normal their cell behaviors of the mutant. Our results indicate that at least a defect in adhesion response for the change in cell surface components (glycoproteins and/or glycolipids).
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言語 |
英語
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資源タイプ | 紀要論文 |
出版者 |
島根大学理学部
The Faculty of Science, Shimane University
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発行日 | 1981-12-20 |
アクセス権 | オープンアクセス |
関連情報 |
[NCID] AN00108106
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